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Yardbarker: Buffalo Bills September 16, 2026 Yardbarker

2026 NFL Week 2 odds: Lines and possibilities for all 16 games

Source: Yardbarker: Buffalo Bills

Week 2 opens with the Detroit Lions visiting the Buffalo Bills on Thursday night, with Buffalo entering the matchup as a 4.5-point favorite. The game also carries the highest over/under of the Week 2 slate at 53.5 points.

Read Full Article at Yardbarker: Buffalo Bills →